![]() Transfection of the mRFP-GFP-LC3 plasmid was evaluated by confocal microscopy. The recombinant Sox8 lentiviral vector (lenti-Sox8) was applied to upregulate the expression of Sox8. MSU crystal-treated human chondrocytes were used to evaluate the function of Sox8. mRNAs of cartilage from MSU-induced gouty arthritis rat model were sequenced. This study aimed to investigate whether MSU crystal-induced cartilage impairment was related to autophagic signaling. The deposition of monosodium urate (MSU) crystals in arthritic joints of gout seriously damages cartilage.
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